Balancing oxygen diffusion and convection in spiral microfluidics to mimic radial biological gradients.


Biological gradients are more than linear, one-dimensional phenomena-they often manifest radial geometries superimposed over tissue features and in turn, elicit a spatial response. In wound healing, injury to tissue produces a hypoxic gradient towards the center of the wound, and wound cells respond to this by secreting growth hormones to promote healing… (More)
DOI: 10.1007/s10544-014-9922-9

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