Balancing immunity and pathology in visceral leishmaniasis

@article{Stanley2007BalancingIA,
  title={Balancing immunity and pathology in visceral leishmaniasis},
  author={Amanda C. Stanley and Christian R. Engwerda},
  journal={Immunology and Cell Biology},
  year={2007},
  volume={85}
}
Experimental visceral leishmaniasis (VL) caused by infection with Leishmania donovani results in the development of organ‐specific immunity in the two main target tissues of infection, the spleen and the liver. The liver is the site of an acute resolving infection associated with the development of inflammatory granulomas around infected Kupffer cells, and resistance to reinfection. Paradoxically, the spleen is an initial site for the generation of cell‐mediated immune responses, but ultimately… 

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