Balancing dormant and self-renewing hematopoietic stem cells.

  title={Balancing dormant and self-renewing hematopoietic stem cells.},
  author={Anne S Wilson and Elisa Laurenti and Andreas Trumpp},
  journal={Current opinion in genetics & development},
  volume={19 5},
The mouse hematopoietic stem cell (HSC) is probably the best-understood somatic stem cell in higher organisms. Recent studies have shown that the highest self-renewal potential is most likely contained within an exceedingly small number of deeply dormant bone marrow HSCs. These stem cells are housed in individual niches that preserve their dormancy via signaling molecules such as Thrombopoietin, Angiopoietins, and Stem Cell Factor. In response to injury cues, dormant HSCs are efficiently… CONTINUE READING

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Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

  • A Foudi, K Hochedlinger, +4 authors H Hock
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  • 2009
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