Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics.

@article{DattaMannan2015BalancingCI,
  title={Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics.},
  author={Amita Datta-Mannan and Arunkumar Thangaraju and Donmienne Leung and Ying Tang and Derrick R. Witcher and Jirong Lu and Victor J Wroblewski},
  journal={mAbs},
  year={2015},
  volume={7 3},
  pages={483-93}
}
Lowering the isoelectric point (pI) through engineering the variable region or framework of an IgG can improve its exposure and half-life via a reduction in clearance mediated through non-specific interactions. As such, net charge is a potentially important property to consider in developing therapeutic IgG molecules having favorable pharmaceutical characteristics. Frequently, it may not be possible to shift the pI of monoclonal antibodies (mAbs) dramatically without the introduction of other… CONTINUE READING
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