Balancing benefit and risk of medicines: a systematic review and classification of available methodologies.

@article{MtIsa2014BalancingBA,
  title={Balancing benefit and risk of medicines: a systematic review and classification of available methodologies.},
  author={Shahrul Mt-Isa and Christine Erikstrup Hallgreen and Nan Wang and Torbj{\"o}rn Callr{\'e}us and Georgy Genov and Ian Hirsch and Stephen F Hobbiger and Kimberley S. Hockley and Davide Luciani and Lawrence D. Phillips and George Quartey and Sinan B. Sarac and Isabelle Stoeckert and Ioanna Tzoulaki and Alain Micaleff and Deborah Ashby},
  journal={Pharmacoepidemiology and drug safety},
  year={2014},
  volume={23 7},
  pages={
          667-78
        }
}
BACKGROUND The need for formal and structured approaches for benefit-risk assessment of medicines is increasing, as is the complexity of the scientific questions addressed before making decisions on the benefit-risk balance of medicines. We systematically collected, appraised and classified available benefit-risk methodologies to facilitate and inform their future use. METHODS A systematic review of publications identified benefit-risk assessment methodologies. Methodologies were appraised on… CONTINUE READING
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