Balancing Selection at the Prion Protein Gene Consistent with Prehistoric Kurulike Epidemics

@article{Mead2003BalancingSA,
  title={Balancing Selection at the Prion Protein Gene Consistent with Prehistoric Kurulike Epidemics},
  author={S. Mead and M. Stumpf and J. Whitfield and J. Beck and M. Poulter and T. Campbell and J. Uphill and D. Goldstein and M. Alpers and E. Fisher and J. Collinge},
  journal={Science},
  year={2003},
  volume={300},
  pages={640 - 643}
}
Kuru is an acquired prion disease largely restricted to the Fore linguistic group of the Papua New Guinea Highlands, which was transmitted during endocannibalistic feasts. Heterozygosity for a common polymorphism in the human prion protein gene (PRNP) confers relative resistance to prion diseases. Elderly survivors of the kuru epidemic, who had multiple exposures at mortuary feasts, are, in marked contrast to younger unexposed Fore, predominantly PRNP 129 heterozygotes. Kuru imposed strong… Expand
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