Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder

Abstract

Germline mutations in PTEN, which encodes a widely expressed phosphatase, was mapped to 10q23 and identified as the susceptibility gene for Cowden syndrome, characterized by macrocephaly and high risks of breast, thyroid, and other cancers. The phenotypic spectrum of PTEN mutations expanded to include autism with macrocephaly only 10 years ago. Neurological… (More)
DOI: 10.1007/s13311-015-0356-8

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Cite this paper

@article{Tilot2015BalancingPA, title={Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder}, author={Amanda K. Tilot and Thomas W. Frazier and Charis Eng}, journal={Neurotherapeutics}, year={2015}, volume={12}, pages={609-619} }