Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

  title={Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.},
  author={Huijing Wang and Cobi J Heijnen and Cindy T. J. van Velthoven and Hanneke L. D. M. Willemen and Yoshihiro Ishikawa and Xinna Zhang and Anil Sood and Anne Vroon and Niels Eijkelkamp and Annemieke Kavelaars},
  journal={The Journal of clinical investigation},
  volume={123 12},
Chronic pain is a major clinical problem, yet the mechanisms underlying the transition from acute to chronic pain remain poorly understood. In mice, reduced expression of GPCR kinase 2 (GRK2) in nociceptors promotes cAMP signaling to the guanine nucleotide exchange factor EPAC1 and prolongs the PGE2-induced increase in pain sensitivity (hyperalgesia). Here we hypothesized that reduction of GRK2 or increased EPAC1 in dorsal root ganglion (DRG) neurons would promote the transition to chronic pain… CONTINUE READING
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