Balanced ubiquitination determines cellular responsiveness to extracellular stimuli

@article{Mukai2012BalancedUD,
  title={Balanced ubiquitination determines cellular responsiveness to extracellular stimuli},
  author={Akiko Mukai and Miki Yamamoto-Hino and Masayuki Komada and Hideyuki Okano and Satoshi Goto},
  journal={Cellular and Molecular Life Sciences},
  year={2012},
  volume={69},
  pages={4007-4016}
}
Signal strength evoked by ligand stimulation is crucial for cellular responses such as fate decision, cell survival/death, secretion, and migration. For example, morphogens are secreted signaling molecules that form concentration gradients within tissues and induce distinct cell fates in a signal strength-dependent manner. In addition to extracellular ligand abundance, the sensitivity of signal-receiving cells to ligands also influences signal strength. Cell sensitivity to ligands is controlled… CONTINUE READING
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