Balanced gene regulation by an embryonic brain non-coding RNA is critical for GABA circuitry in adult hippocampus

@inproceedings{Bond2009BalancedGR,
  title={Balanced gene regulation by an embryonic brain non-coding RNA is critical for GABA circuitry in adult hippocampus},
  author={Allison M. Bond and Michael J. W. VanGompel and Evgeny A. Sametsky and Mary F. Clark and Julie C. Savage and John F. Disterhoft and Jhumku D. Kohtz},
  booktitle={Nature Neuroscience},
  year={2009}
}
Genomic studies demonstrate that, although the majority of the mammalian genome is transcribed, only about 2% of these transcripts are code for proteins. We investigated how the long, polyadenylated Evf2 noncoding RNA regulates transcription of the homeodomain transcription factors DLX5 and DLX6 in the developing mouse forebrain. We found that, in developing ventral forebrain, Evf2 recruited DLX and MECP2 transcription factors to important DNA regulatory elements in the Dlx5/6 intergenic region… CONTINUE READING

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