Balanced Pharmacokinetics and Metabolism of Bisoprolol

@article{Leopold1986BalancedPA,
  title={Balanced Pharmacokinetics and Metabolism of Bisoprolol},
  author={G. Leopold},
  journal={Journal of Cardiovascular Pharmacology},
  year={1986},
  volume={8},
  pages={S16–S20}
}
  • G. Leopold
  • Published 1 November 1985
  • Medicine
  • Journal of Cardiovascular Pharmacology
&NA; Bisoprolol exhibits a high absolute bioavailability (90%) because of its nearly complete absorption (> 90%) and small first‐pass effect (10%). Bioavailability is independent of food intake. A long plasma‐elimination half‐life (10‐11 h) allows a once‐a‐day dose regimen. Because of the low plasma protein‐binding (30%), kinetics are insensitive to protein‐binding interactions. The balanced clearance (equieffective hepatic and renal clearance) renders the kinetics virtually insensitive to… Expand
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