Balance of purines may determine life or death of retinal ganglion cells as A3 adenosine receptors prevent loss following P2X7 receptor stimulation.

@article{Zhang2006BalanceOP,
  title={Balance of purines may determine life or death of retinal ganglion cells as A3 adenosine receptors prevent loss following P2X7 receptor stimulation.},
  author={Xiulan Zhang and Mei Zhang and Alan M. Laties and Claire H. Mitchell},
  journal={Journal of neurochemistry},
  year={2006},
  volume={98 2},
  pages={566-75}
}
The purines ATP and adenosine can act as a coordinated team of transmitters. As extracellular adenosine is frequently derived from the enzymatic dephosphorylation of released ATP, the distinct actions of the two purines can be synchronized. In retinal ganglion cells (RGCs), stimulation of the P2X7 receptor for ATP leads to increased intracellular Ca2+ and death. Here we define the contrasting effects of adenosine and identify protective actions mediated by the A3 receptor. Adenosine attenuated… CONTINUE READING

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