Balance between neurogenesis and gliogenesis in the adult hippocampus: role for reelin.

@article{Zhao2007BalanceBN,
  title={Balance between neurogenesis and gliogenesis in the adult hippocampus: role for reelin.},
  author={Shanting Zhao and Xuejun Chai and Michael Frotscher},
  journal={Developmental neuroscience},
  year={2007},
  volume={29 1-2},
  pages={84-90}
}
The extracellular matrix protein reelin is essential for the proper radial migration of cortical neurons. In reeler mice lacking reelin, there is a malformation of the radial glial scaffold required for granule cell migration. Immunostaining for glial fibrillary acidic protein (GFAP) reveals abundant radial glial cells with long fibers traversing the granular layer in the wild type, but almost exclusively astrocytes in the reeler mutant. With the concept that radial glial cells are precursors… CONTINUE READING
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Dentate granule cells

  • M Frotscher
  • 2002
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