Balance between SIRT1 and DBC1 expression is lost in breast cancer.

@article{Sung2010BalanceBS,
  title={Balance between SIRT1 and DBC1 expression is lost in breast cancer.},
  author={Ji-youn Sung and Ranah Kim and J T Kim and Juhie Lee},
  journal={Cancer science},
  year={2010},
  volume={101 7},
  pages={1738-44}
}
SIRT1 (silent mating-type information regulation 2 homologue 1)-mediated cellular resistance to various stresses is negatively regulated by deleted in breast cancer 1 (DBC1), which was originally reported to be deleted in breast cancer. However, the suggested functions of SIRT1 as a potential tumor promoter and of DBC1 as a potential tumor suppressor have been challenged by observations of their respective down- and up-regulation in various cancers. The aim of the present study was to… CONTINUE READING