Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities.

@article{Wang2009BakkenolidesFP,
  title={Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities.},
  author={Yuliang Wang and Run-ping Li and Mei-li Guo and Ge Zhang and Na Zhang and Yan-Li Ma},
  journal={Planta medica},
  year={2009},
  volume={75 3},
  pages={230-5}
}
Four novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa ( 2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) - were isolated from the extract of the rhizome of Petasites tricholobus. The structures were characterized by using NMR ( (1)H, (13)C, (1)H- (1)H COSY, HMQC, HMBC, and NOESY) and mass spectrometry. The neuroprotective activity of the compounds 1 - 4 was assayed with primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults. Antioxidant activity of the… CONTINUE READING