Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization

@inproceedings{Pang2012BakCC,
  title={Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization},
  author={Yew Choi Pang and Henchange Dai and Alyson J. Smith and Xue Wei Meng and Paula Anne Schneider and Scott H. Kaufmann},
  booktitle={Scientific reports},
  year={2012}
}
Recently we reported that the BH3-only proteins Bim and Noxa bind tightly but transiently to the BH3-binding groove of Bak to initiate Bak homo-oligomerization. However, it is unclear how such tight binding can induce Bak homo-oligomerization. Here we report the ligand-induced Bak conformational changes observed in 3D models of Noxa·Bak and Bim·Bak refined by molecular dynamics simulations. In particular, upon binding to the BH3-binding groove, Bim and Noxa induce a large conformational change… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

The Bcl2 family: regulators of the cellular life-or-death switch

  • Nature Reviews Cancer
  • 2002
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

AutoCAD 2012 for Mac Version F.51.M.57 (Autodesk Inc

LLC, OR Portland
  • 2012

Opening the Cellular Poison Cabinet

S. J. Martin
  • Science 330,
  • 2010