Baincalein alleviates early brain injury after experimental subarachnoid hemorrhage in rats: possible involvement of TLR4/NF-κB-mediated inflammatory pathway.

@article{Wang2015BaincaleinAE,
  title={Baincalein alleviates early brain injury after experimental subarachnoid hemorrhage in rats: possible involvement of TLR4/NF-κB-mediated inflammatory pathway.},
  author={Chun-xi Wang and Guang-bin Xie and Chen-hui Zhou and Xiang-Sheng Zhang and Tao Li and Jian-guo Xu and Ning Li and Ke Ding and Chun-hua Hang and Ji-Xin Shi and Meng-liang Zhou},
  journal={Brain research},
  year={2015},
  volume={1594},
  pages={245-55}
}
Early brain injury (EBI) following subarachnoid hemorrhage (SAH) largely contributes to unfavorable outcomes. Hence, effective therapeutic strategies targeting on EBI have recently become a major goal in the treatment of SAH patients. Baicalein is a flavonoid that has been shown to offer neuroprotection in kinds of brain injury models. This study investigated the effects of baicalein on EBI in rats following SAH. SAH was inducted in male Sprauge-Dawley rats by injection of fresh non-heparinized… CONTINUE READING
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