Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice.

@article{Zhang2018BaicalinAN,
  title={Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice.},
  author={Junli Zhang and Haiming Zhang and Xiaoling Deng and Ning Zhang and Beibei Liu and Shengliang Xin and Guixin Li and Keshu Xu},
  journal={Life sciences},
  year={2018},
  volume={192},
  pages={46-54}
}
AIMS Baicalin (BA), an active flavonoid compound originating from the herb of Scutellaria baicalensis Georgi, has been previously shown to exert anti-inflammation and anti-oxidant effects in liver diseases. However, the potential role of BA in the regulation of non-alcoholic steatohepatitis (NASH) remains elusive. In this study, we newly explored the hepatoprotective effects of BA in MCD diet-induced NASH by ameliorating hepatic steatosis, inflammation, fibrosis and apoptosis. MAIN METHODS… CONTINUE READING