Baicalin Attenuates Ketamine-Induced Neurotoxicity in the Developing Rats: Involvement of PI3K/Akt and CREB/BDNF/Bcl-2 Pathways

@article{Zuo2016BaicalinAK,
  title={Baicalin Attenuates Ketamine-Induced Neurotoxicity in the Developing Rats: Involvement of PI3K/Akt and CREB/BDNF/Bcl-2 Pathways},
  author={Daiying Zuo and Li Lin and Yumiao Liu and Chengna Wang and Jingwen Xu and Feng Sun and Lin Li and Zengqiang Li and Yingliang Wu},
  journal={Neurotoxicity Research},
  year={2016},
  volume={30},
  pages={159-172}
}
Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic neurotoxicity in the cortex and hippocampus of the Sprague–Dawley postnatal day 7 (PND7) rat pups. Our results revealed that five continuous injections of ketamine (20 mg/kg) at… CONTINUE READING

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