Baicalein inhibits adipocyte differentiation by enhancing COX-2 expression.

  title={Baicalein inhibits adipocyte differentiation by enhancing COX-2 expression.},
  author={Min Ho Cha and I Kim and B Lee and Yoosik Yoon},
  journal={Journal of medicinal food},
  volume={9 2},
Baicalein, one of the major flavonoids in Scutellaria baicalensis (Chinese Skullcap), is well known for its effects on cell proliferation, apoptosis, and inflammation. Here we show that baicalein also inhibits the adipogenesis of 3T3-L1 preadipocytes. Baicalein inhibited triglyceride accumulation during adipogenesis and significantly decreased the mRNA expression of fatty acid-binding protein (FABP), a marker of adipogenesis. Microarray analysis revealed that several genes, which are… CONTINUE READING