Baicalein induces functional hypoxia-inducible factor-1alpha and angiogenesis.

  title={Baicalein induces functional hypoxia-inducible factor-1alpha and angiogenesis.},
  author={Hyunju Cho and H J Lee and Dae-Ro Ahn and Seong Yoon Kim and Sunyun Kim and Keun Byeol Lee and You Mie Lee and Hyunsung Park and Eun Gyeong Yang},
  journal={Molecular pharmacology},
  volume={74 1},
Targeting the oxygen-sensing mechanisms of the hypoxiainducible factor (HIF) pathway provides pharmacological ways of manipulating the HIF response. Because HIF-1alpha-specific prolyl-4 hydroxylases (PHDs) prime degradation of HIF-1alpha, we have made an effort to find a small molecule capable of up-regulating the HIF pathway by inhibiting prolyl hydroxylation. Through an in vitro high-throughput screen, we have discovered a PHD2 inhibitor baicalein, which is also found to abrogate asparaginyl… CONTINUE READING


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