Baicalein attenuates oxidant stress in cardiomyocytes.

  title={Baicalein attenuates oxidant stress in cardiomyocytes.},
  author={Z Shao and Terry L. Vanden Hoek and Yimin Qin and Lance B. Becker and Paul T Schumacker and Chang-qing Li and L. T. Dey and Eugene D. Barth and Howard Halpern and Gerald Rosen and Chun-su Yuan},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={282 3},
Flavonoids within Scutellaria baicalensis may be potent antioxidants on the basis of our studies of S. baicalensis extract. To further this work, we studied the antioxidative effects of baicalein, a flavonoid component of S. baicalensis, in a chick cardiomyocyte model of reactive oxygen species (ROS) generation during hypoxia, simulated ischemia-reperfusion, or mitochondrial complex III inhibition with antimycin A. Oxidant stress was measured by oxidation of the intracellular probes 2',7… CONTINUE READING