Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo.

@article{Hung2016BaicaleinA,
  title={Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo.},
  author={Kai-Chih Hung and Hui-Ju Huang and Yi-Ting Wang and Anya Maan-yuh Lin},
  journal={Journal of ethnopharmacology},
  year={2016},
  volume={194},
  pages={522-529}
}
ETHNOPHARMACOLOGICAL RELEVANCE Neuroinflammation, oxidative stress, and protein aggregation form a vicious cycle in the pathophysiology of Parkinson's disease (PD); activated microglia is the main location of neuroinflammation. A Chinese medicine book, "Shanghan Lun", known as the "Treatises on Cold damage Diseases" has suggested that Scutellaria baicalensis Georgi is effective in treating CNS diseases. The anti-inflammatory mechanisms of baicalein, a phenolic flavonoid in the dried root of… CONTINUE READING