Baicalein, an active component of Scutellaria baicalensis Georgi, prevents lysophosphatidylcholine-induced cardiac injury by reducing reactive oxygen species production, calcium overload and apoptosis via MAPK pathways

@inproceedings{Chen2014BaicaleinAA,
  title={Baicalein, an active component of Scutellaria baicalensis Georgi, prevents lysophosphatidylcholine-induced cardiac injury by reducing reactive oxygen species production, calcium overload and apoptosis via MAPK pathways},
  author={Huai-min Chen and Jong-Hau Hsu and Shu-Fen Liou and T J Chen and Li-Ying Chen and Chaw-chi Chiu and Jwu-Lai Yeh},
  booktitle={BMC complementary and alternative medicine},
  year={2014}
}
BACKGROUND Lysophosphatidylcholine (lysoPC), a metabolite from membrane phospholipids, accumulates in the ischemic myocardium and plays an important role in the development of myocardial dysfunction ventricular arrhythmia. In this study, we investigated if baicalein, a major component of Huang Qui, can protect against lysoPC-induced cytotoxicity in rat H9c2 embryonic cardiomyocytes. METHODS Cell viability was detected by the MTT assay; ROS levels were assessed using DCFH-DA; and intracellular… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Similar Papers

Loading similar papers…