Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209


Bafilomycins (Figure 1), macrolide antibiotics with a 16-membered lactone ring as their defining structural scaffold, are produced by a variety of streptomycetes.1–5 These macrolides exhibit a variety of biological activities, including antitumor,6 antifungal,7 antiparasitic8 and immunosuppressant activities.9 In particular, bafilomycin A1 is an extremely… (More)
DOI: 10.1038/ja.2010.147


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