Bafilomycin A1 and its attenuating effect on tumour growth in systemic malignancies, especially gastrointestinal malignancies.

@article{Kapoor2013BafilomycinAA,
  title={Bafilomycin A1 and its attenuating effect on tumour growth in systemic malignancies, especially gastrointestinal malignancies.},
  author={Shailendra Kapoor},
  journal={Clinical science},
  year={2013},
  volume={125 4},
  pages={
          219
        }
}
  • S. Kapoor
  • Published 1 August 2013
  • Medicine
  • Clinical science
The paper by Wang et al. [1] published in Clinical Science provided for highly interesting reading. Interestingly, recent data confirms that bafilomycin A1 decreases tumour growth in a number of systemic malignancies. For instance, it decreases growth in colonic malignancies. It mediates its antineoplastic effects by attenuating lysosomal acidification within the cancerous … The paper by Wang et al. [1] published in Clinical Science provided for highly interesting reading. Interestingly… 
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It is shown that BafA1 at nanomolar concentrations suppresses HCC cell growth in both 2 dimensional (2D) and 3D cultures, and pharmacological inhibition of JNK with SP600125 enhanced BAFA1-mediated cytotoxicity both in vitro and in xenografts derived from HCC cells.
The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma
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Data point to ATP6V1G1 as a novel marker of poor prognosis in GBM patients and identify V-ATPase inhibition as an innovative therapeutic strategy for GBM.

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Observations suggest that bafilomycin A1 inhibits the growth of Capan‐1 human pancreatic cancer cells through apoptosis, a specific inhibitor of vacuolar type H+‐ATPase.
Bafilomycin Induces the p21-Mediated Growth Inhibition of Cancer Cells under Hypoxic Conditions by Expressing Hypoxia-Inducible Factor-1α
TLDR
Bafilomycin A1 and its analog, concanamycin A, were found to up-regulate HIF-1α in eight human cancer cell-lines, and this effect is attributed to inhibited degradation of Hif-1 α protein.
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TLDR
The combination of bafilomycine A1 and EIPA significantly lowered pHi and increased thermosensitivity of cancer cells in vitro and enhanced the heat-induced the growth delay of AsPC-1 tumours grown s.c in the legs of BALB/cA nude mice.
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TLDR
Induction of autophagy led to a down-regulation of VPRPB, which could be rescued by the inhibition ofAutophagy degradation by BFA1 (bafilomycin A1) and by the disruption of Autophagy through ATG5-knockdown.
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TLDR
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