Baff Mediates Survival of Peripheral Immature B Lymphocytes

  title={Baff Mediates Survival of Peripheral Immature B Lymphocytes},
  author={Marcel Batten and Joanna R. Groom and Teresa G. Cachero and Fang Qian and Pascal Schneider and Jürg Tschopp and Jeffrey L. Browning and Fabienne Mackay},
  journal={The Journal of Experimental Medicine},
  pages={1453 - 1466}
B cell maturation is a very selective process that requires finely tuned differentiation and survival signals. B cell activation factor from the TNF family (BAFF) is a TNF family member that binds to B cells and potentiates B cell receptor (BCR)-mediated proliferation. A role for BAFF in B cell survival was suggested by the observation of reduced peripheral B cell numbers in mice treated with reagents blocking BAFF, and high Bcl-2 levels detected in B cells from BAFF transgenic (Tg) mice. We… 

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