Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.

@article{Kelekar1997BadIA,
  title={Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.},
  author={Ameeta Kelekar and Brian S. Chang and John E. Harlan and Stephen W. Fesik and Craig B Thompson},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 12},
  pages={
          7040-6
        }
}
The Bcl-2 related protein Bad is a promoter of apoptosis and has been shown to dimerize with the anti-apoptotic proteins Bcl-2 and Bcl-XL. Overexpression of Bad in murine FL5.12 cells demonstrated that the protein not only could abrogate the protective capacity of coexpressed Bcl-XL but could accelerate the apoptotic response to a death signal when it was expressed in the absence of exogenous Bcl-XL. Using deletion analysis, we have identified the minimal domain in the murine Bad protein that… CONTINUE READING

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