Baculovirus virions displaying infectious bursal disease virus VP2 protein protect chickens against infectious bursal disease virus infection.

@article{Xu2011BaculovirusVD,
  title={Baculovirus virions displaying infectious bursal disease virus VP2 protein protect chickens against infectious bursal disease virus infection.},
  author={Xingang Xu and De-Wen Tong and Zhi Sheng Wang and Qi Zhang and Zhao-Cai Li and Kuan Zhang and Wei Li and Hung-Jen Liu},
  journal={Avian diseases},
  year={2011},
  volume={55 2},
  pages={
          223-9
        }
}
Infectious bursal disease (IBD) is an acute and contagious viral infection of young chickens caused by IBD virus (IBDV). The VP2 protein of IBDV is the only antigen for inducing neutralizing antibodies and protective immunity in the natural host. In the current study, we have succeeded in construction of one recombinant baculovirus BacSC-VP2 expressing His6-tagged VP2 with the baculovirus envelope protein gp64 transmembrane domain (TM) and cytoplasmic domain (CTD). The His6-tagged recombinant… CONTINUE READING
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