Baculovirus vectors: novel mammalian cell gene-delivery vehicles and their applications.

@article{Hser2003BaculovirusVN,
  title={Baculovirus vectors: novel mammalian cell gene-delivery vehicles and their applications.},
  author={Andreas H{\"u}ser and Christian Hofmann},
  journal={American journal of pharmacogenomics : genomics-related research in drug development and clinical practice},
  year={2003},
  volume={3 1},
  pages={53-63}
}
Various methods have been developed to transfer and express genes in mammalian cells. Each method, whether virally, non-virally, or physically-based, has unique favorable features, but also drawbacks with respect to meeting desired and specific needs. Baculoviruses have been used since 1983 to express recombinant genes controlled by strong insect-virus promoters in their natural host (insect) cells. Today this is a well-established and easy to handle system for producing large quantities of… CONTINUE READING