Baculovirus-based genetic screen for antiapoptotic genes identifies a novel IAP.

@article{Seshagiri1999BaculovirusbasedGS,
  title={Baculovirus-based genetic screen for antiapoptotic genes identifies a novel IAP.},
  author={Somasekar Seshagiri and Domagoj Vucic and Jung-Ho Lee and Vishva M. Dixit},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 51},
  pages={36769-73}
}
The prototype baculovirus, Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) expresses p35, a potent anti cell-death gene that promotes the propagation of the virus by blocking host cell apoptosis. Infection of insect Sf-21 cells with AcMNPV lacking p35 induces apoptosis. We have used this pro-apoptotic property of the p35 null virus to screen for genes encoding inhibitors of apoptosis that rescue cells infected with the p35 defective virus. We report here the identification… CONTINUE READING

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