Baculovirus Lymantria dispar multiple nucleopolyhedrovirus IAP2 and IAP3 do not suppress apoptosis, but trigger apoptosis of insect cells in a transient expression assay

@article{Yamada2012BaculovirusLD,
  title={Baculovirus Lymantria dispar multiple nucleopolyhedrovirus IAP2 and IAP3 do not suppress apoptosis, but trigger apoptosis of insect cells in a transient expression assay},
  author={Hayato Yamada and Miyuki Shibuya and Michihiro Kobayashi and Motoko Ikeda},
  journal={Virus Genes},
  year={2012},
  volume={45},
  pages={370-379}
}
Ld652Y cells derived from the gypsy moth, Lymantria dispar, are permissive for productive infection with L. dispar multiple nucleopolyhedrovirus (LdMNPV), but undergo apoptosis upon infection with various other NPVs, including those isolated from Bombyx mori, Hyphantria cunea, Spodoptera exigua, Orgyia pseudotsugata, and Spodoptera litura. In this study, we examined whether LdMNPV-encoded inhibitor of apoptosis 2 (Ld-IAP2) and 3 (Ld-IAP3) are involved in apoptosis suppression in LdMNPV-infected… CONTINUE READING
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