Bacteroides gingivalis fimbriae stimulate production of thymocyte-activating factor by human gingival fibroblasts

@article{Hanazawa1988BacteroidesGF,
  title={Bacteroides gingivalis fimbriae stimulate production of thymocyte-activating factor by human gingival fibroblasts},
  author={Shigemasa Hanazawa and Kimiharu Hirose and Yoshihiro Ohmori and Shigeru Amano and Shigeo Kitano},
  journal={Infection and Immunity},
  year={1988},
  volume={56},
  pages={272 - 274}
}
In a previous report (Y. Ohmori, S. Hanazawa, S. Amano, T. Miyoshi, K. Hirose, and S. Kitano, infect. Immun. 55:947-954, 1987), we showed that human gingival fibroblasts spontaneously produce thymocyte-activating factor (FTAF), which stimulates mitogen-induced thymocyte proliferation. In the present study, we examined the effect of Bacteroides gingivalis fimbriae on FTAF production by the cells, because the fimbriae may be involved in attachment of the organism to periodontal tissues. We show… 
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The observations suggest that gingival fibroblasts play a significant role in regulation of cell growth of lymphocytes and in their own growth under physiological conditions and in pathological states in periodontal connective tissue.
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