Bacteroides fragilis synthesizes a DNA invertase affecting both a local and a distant region.
@article{RocheHakansson2007BacteroidesFS, title={Bacteroides fragilis synthesizes a DNA invertase affecting both a local and a distant region.}, author={Hazeline Roche-Hakansson and Maria Chatzidaki-Livanis and M. Coyne and L. Comstock}, journal={Journal of bacteriology}, year={2007}, volume={189 5}, pages={ 2119-24 } }
The activity of a fourth conserved tyrosine site-specific recombinase (Tsr) of Bacteroides fragilis was characterized. Its gene, tsr19, is adjacent to mpi, encoding the global DNA invertase regulating capsular polysaccharide biosynthesis. Unlike the other described Tsrs of B. fragilis, Tsr19 brings about inversion of two DNA regions, one local and one located distantly.
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References
SHOWING 1-6 OF 6 REFERENCES
Extensive DNA Inversions in the B. fragilis Genome Control Variable Gene Expression
- Biology, Medicine
- Science
- 2005
- 252
- PDF
Analysis of cepA and other Bacteroides fragilis genes reveals a unique promoter structure.
- Biology, Medicine
- FEMS microbiology letters
- 2000
- 130
Tyrosine site‐specific recombinases mediate DNA inversions affecting the expression of outer surface proteins of Bacteroides fragilis
- Biology, Medicine
- Molecular microbiology
- 2004
- 38
Mpi recombinase globally modulates the surface architecture of a human commensal bacterium
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2003
- 83
- PDF
Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2004
- 206
- Highly Influential
- PDF