Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis

@article{Ramakrishna2019BacteroidesFP,
  title={Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis},
  author={Chandran Ramakrishna and Maciej W. Kujawski and Hiutung Chu and Lin Li and Sarkis K. Mazmanian and Edouard M. Cantin},
  journal={Nature Communications},
  year={2019},
  volume={10}
}
The gut commensal Bacteroides fragilis or its capsular polysaccharide A (PSA) can prevent various peripheral and CNS sterile inflammatory disorders. Fatal herpes simplex encephalitis (HSE) results from immune pathology caused by uncontrolled invasion of the brainstem by inflammatory monocytes and neutrophils. Here we assess the immunomodulatory potential of PSA in HSE by infecting PSA or PBS treated 129S6 mice with HSV1, followed by delayed Acyclovir (ACV) treatment as often occurs in the… 

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