Bacteroides fragilis-derived lipopolysaccharide produces cell activation and lethal toxicity via toll-like receptor 4.

@article{Mancuso2005BacteroidesFL,
  title={Bacteroides fragilis-derived lipopolysaccharide produces cell activation and lethal toxicity via toll-like receptor 4.},
  author={Giuseppe Mancuso and Angelina Midiri and Carmelo Biondo and Concetta Beninati and Maria Elsa Gambuzza and Daniele Macr{\`i} and Antonella Bellantoni and Andrej Weintraub and Terje Espevik and Giuseppe Teti},
  journal={Infection and immunity},
  year={2005},
  volume={73 9},
  pages={5620-7}
}
Bacteroides fragilis, which is part of the normal intestinal flora, is a frequent cause of serious disease, especially in diabetic and surgical patients. In these conditions, B. fragilis lipopolysaccharide (LPS) is likely to play a major pathophysiologic role. B. fragilis LPS is structurally different from classical enterobacterial LPS, whose biological activities are mediated by Toll-like receptor 4 (TLR4) activation. The ability of B. fragilis LPS to activate TLR4 and TLR2 was investigated… CONTINUE READING

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