• Corpus ID: 28851496

Bacteriophage therapy: an alternative to conventional antibiotics.

  title={Bacteriophage therapy: an alternative to conventional antibiotics.},
  author={M. D. Mathur and S Vidhani and P L Mehndiratta},
  journal={The Journal of the Association of Physicians of India},
Bacteriophage therapy is an important alternative to antibiotics in the current era of multidrug resistant pathogens. We reviewed the studies that dealt with the therapeutic use of phages from 1966-1996 and few latest ongoing phage therapy projects via internet. Phages were used topically, orally or systemically in Polish and Soviet studies. The success rate found in these studies was 80-95% with few gastrointeslinal or allergic side effects. British studies also demonstrated significant… 
Lytic Bacteriophages and Phage Cocktails Seem to be a Future Alternative Against Multi-Drug Resistant Bacterial Infections
The present review mainly focused on the efficacy of bacteriophages and cocktails as theraupatic agents against predominate MDR-bacteria and their biofilms which are isolated from septic wound infections.
Bacteriophages: their use in the treatment of infections in the future
Using bacteriophages for the treatment of infections could be an effective alternative to antibiotics, and studies reveal their effective use in a wide variety of infections.
Prospects of Inhaled Phage Therapy for Combatting Pulmonary Infections
The use of electrospray for targeted delivery, advances in nebulization techniques, individualized controlled inhalation with software control, and liposome-encapsulated nebulized phages to take pulmonary phage delivery to the next level are detailed.
Bacteriophages: an overview of the control strategies against multiple bacterial infections in different fields
This review is an effort to collect almost recent and relevant information regarding applications and complications associated with the use of bacteriophages.
Bacteriophages as a Alternative Option to Alleviate the Prevailing Crisis of Antimicrobial Resistance
Antimicrobial resistance as defined by WHO, is a natural phenomenon which includes all forms of resistance to medicines on the part of viral, parasitic, fungal or bacterial infections (Carlet, 2015).
Phage Therapy; A Review on the Biology and Therapeutic Application of Bacteriophage
The effectiveness of phage applications against pathogenic bacteria depends on several factors such as the bacteriophage/bacteria ratio, physico-chemical factors, phage neutralization or resistance to phage.
Application of Therapeutic Phages in Medicine
Exploring alternative approaches to develop antibacterial products is also a worthwhile task, and re-examining the potential of promising older methods might be of value.
8 Application of Therapeutic Phages in Medicine
Exploring alternative approaches to develop antibacterial products is also a worthwhile task, and re-examining the potential of promising older methods might be of value.
Bacteriophage therapy as a bacterial control strategy in aquaculture
The need of further research is emphasized in the field of the application of phage therapy in aquaculture and the use of phages in invertebrates as an antimicrobial strategy is highlighted, pointing critical aspects from the economic, environmental and public health perspectives.
Facing Antibiotic Resistance: Staphylococcus aureus Phages as a Medical Tool
An overview of current knowledge on staphylococcal infections and bacteriophages able to kill Staphylitis, including experimental studies and available data on their clinical use is presented.


Long-circulating bacteriophage as antibacterial agents.
  • C. MerrilB. Biswas S. Adhya
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1996
A serial-passage technique in mice is developed to select for phage mutants able to remain in the circulatory system for longer periods of time and it is demonstrated that the long-circulating lambda mutants also have greater capability as antibacterial agents than the corresponding parental strain in animals infected with lethal doses of bacteria.
Bacteriophage therapy of infectious diseases in aquaculture.
Prevalence of Broad-Host-Range Lytic Bacteriophages of Sphaerotilus natans, Escherichia coli, andPseudomonas aeruginosa
It is suggested that broad-host-range bacteriophages play a key role in phage ecology and gene transfer in nature and a multiple-host enrichment protocol may be more effective for the isolation of broad- host-range phages by avoiding the selection bias inherent in single-host methods.
Fate of Bacteriophage Lambda in Non-immune Germ-free Mice
The use of bacteriophage in such studies offers a sensitive tool to augment materials such as dyes, radioactive colloids and enzymes for analysing mechanisms of handling foreign particulate material and may enhance the general understanding of virus–host interactions.
Bacteriophage prevents destruction of skin grafts by Pseudomonas aeruginosa.
  • J. Soothill
  • Biology, Medicine
    Burns : journal of the International Society for Burn Injuries
  • 1994
Bacterial and Bacteriophage Genetics
  • E. Birge
  • Biology
    Springer Series in Microbiology
  • 1981
Preface to the Fourth Edition of Bacterial and Viral Genetics: Generally and Specifically Recombination, Applied Bacterial Genetics and Bacterial Evolution.
The Principles of Bacteriology and Immunity
T OPLEY AND WILSON'S great two-volume work is now in one volume at $12..oo (formerly $iS.OO)-in England 5 ° s-Most up to date and authoritative presentation of these subjects in existence. More than
Bacteriophages show promise as antimicrobial agents.
Successful treatment of experimental Escherichia coli infections in mice using phage: its general superiority over antibiotics.
A single intramuscular dose of one anti-K1 phage was more effective than multiple intamuscular does of tetracycline, ampicillin, chloramphenicol, or trimethoprim plus sulphafurazole in curing mice of a potentially lethal intramucularly or intracerebrally induced infection of MW; it was at least as effective as multiple intramUScular doses of streptomycin.