Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials.

@article{GordilloAltamirano2021BacteriophageresistantA,
  title={Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials.},
  author={Fernando L. Gordillo Altamirano and John H. Forsyth and Ruzeen Rohintan Patwa and Xenia Kostoulias and Michael Trim and Dinesh Subedi and Stuart K Archer and Faye C. Morris and Cody Oliveira and Luisa Kielty and Denis V. Korneev and Moira K. O’Bryan and Trevor J Lithgow and Anton Y. Peleg and Jeremy J. Barr},
  journal={Nature microbiology},
  year={2021}
}
We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of Acinetobacter baumannii and established that the bacterial capsule is the receptor for these phages. Phage-resistant mutants harboured loss-of-function mutations in genes responsible for capsule biosynthesis, resulting in capsule loss and disruption of phage adsorption. The phage-resistant strains were resensitized to human complement, beta-lactam antibiotics and alternative phages and exhibited diminished… 
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