Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system

@article{BondyDenomy2013BacteriophageGT,
  title={Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system},
  author={Joseph Bondy-Denomy and April Pawluk and K. Maxwell and A. Davidson},
  journal={Nature},
  year={2013},
  volume={493},
  pages={429 - 432}
}
A widespread system used by bacteria for protection against potentially dangerous foreign DNA molecules consists of the clustered regularly interspaced short palindromic repeats (CRISPR) coupled with cas (CRISPR-associated) genes. Similar to RNA interference in eukaryotes, these CRISPR/Cas systems use small RNAs for sequence-specific detection and neutralization of invading genomes. Here we describe the first examples of genes that mediate the inhibition of a CRISPR/Cas system. Five distinct… Expand
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