Bacteriophage adhering to mucus provide a non-host-derived immunity.

@article{Barr2013BacteriophageAT,
  title={Bacteriophage adhering to mucus provide a non-host-derived immunity.},
  author={Jeremy J Barr and Rita Auro and Mike Furlan and Katrine Whiteson and Marcella L. Erb and Joe Pogliano and Aleksandr Stotland and Roland Wolkowicz and Andrew S. Cutting and Kelly S. Doran and Peter Salamon and Merry Youle and Forest Rohwer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 26},
  pages={10771-6}
}
Mucosal surfaces are a main entry point for pathogens and the principal sites of defense against infection. Both bacteria and phage are associated with this mucus. Here we show that phage-to-bacteria ratios were increased, relative to the adjacent environment, on all mucosal surfaces sampled, ranging from cnidarians to humans. In vitro studies of tissue culture cells with and without surface mucus demonstrated that this increase in phage abundance is mucus dependent and protects the underlying… CONTINUE READING

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