Bacteriophage T7 DNA replication. An electron microscopic study of the growing point and the role of the T7 gene 4 protein in the formation of DNA fragments.


T7 gene 4 codes for a protein whose function is essential for the replication of the viral chromosome. The experiments reported in this paper were designed to study the mechanism of action of T7 gene 4 by assessing the change that occurs in intracellular viral DNA when the gene 4 protein is inactivated during a normal DNA replication cycle. Following… (More)


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