Bacteriophage SPP1 Chu is an alkaline exonuclease in the SynExo family of viral two-component recombinases.

@article{Vellani2003BacteriophageSC,
  title={Bacteriophage SPP1 Chu is an alkaline exonuclease in the SynExo family of viral two-component recombinases.},
  author={Trina S Vellani and Richard S Myers},
  journal={Journal of bacteriology},
  year={2003},
  volume={185 8},
  pages={2465-74}
}
Many DNA viruses concatemerize their genomes as a prerequisite to packaging into capsids. Concatemerization arises from either replication or homologous recombination. Replication is already the target of many antiviral drugs, and viral recombinases are an attractive target for drug design, particularly for combination therapy with replication inhibitors, due to their important supporting role in viral growth. To dissect the molecular mechanisms of viral recombination, we and others previously… CONTINUE READING