Bacteriophage-Resistant Staphylococcus aureus Mutant Confers Broad Immunity against Staphylococcal Infection in Mice

@inproceedings{Capparelli2010BacteriophageResistantSA,
  title={Bacteriophage-Resistant Staphylococcus aureus Mutant Confers Broad Immunity against Staphylococcal Infection in Mice},
  author={Rosanna Capparelli and Nunzia Nocerino and Rosa Lanzetta and Alba Silipo and Angela Amoresano and Chiara Giangrande and Karsten Becker and Giuseppe Blaiotta and Antonio Evidente and Alessio Cimmino and Marco Iannaccone and Marianna Parlato and Chiara Medaglia and S Roperto and Franco Peppino Roperto and Luigi Ramunno and Domenico Iannelli},
  booktitle={PloS one},
  year={2010}
}
In the presence of a bacteriophage (a bacteria-attacking virus) resistance is clearly beneficial to the bacteria. As expected in such conditions, resistant bacteria emerge rapidly. However, in the absence of the phage, resistant bacteria often display reduced fitness, compared to their sensitive counterparts. The present study explored the fitness cost associated with phage-resistance as an opportunity to isolate an attenuated strain of S. aureus. The phage-resistant strain A172 was isolated… CONTINUE READING