Bacteriophage Polysaccharide Depolymerases and Biomedical Applications

@article{Yan2013BacteriophagePD,
  title={Bacteriophage Polysaccharide Depolymerases and Biomedical Applications},
  author={Jianlong Yan and Jiaoxiao Mao and Jianping Xie},
  journal={BioDrugs},
  year={2013},
  volume={28},
  pages={265-274}
}
Polysaccharide depolymerase, a polysaccharide hydrolase encoded by bacteriophages (or ‘phages’), can specifically degrade the macromolecule carbohydrates of the host bacterial envelope. This enzyme assists the bacteriophage in adsorbing, invading, and disintegrating the host bacteria. Polysaccharide depolymerase activity continues even within biofilms. This effectiveness means phages are promising candidates for novel antibiotic scaffolds. A comprehensive compendium of bacteriophage… CONTINUE READING
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