Bacteriophage Endolysins as a Novel Class of Antibacterial Agents

@article{Borysowski2006BacteriophageEA,
  title={Bacteriophage Endolysins as a Novel Class of Antibacterial Agents},
  author={Jan Borysowski and Beata Weber-Dąbrowska and Andrzej G{\'o}rski},
  journal={Experimental Biology and Medicine},
  year={2006},
  volume={231},
  pages={366 - 377}
}
Endolysins are double-stranded DNA bacteriophage-encoded peptidoglycan hydrolases produced in phage-infected bacterial cells toward the end of the lytic cycle. They reach the peptidoglycan through membrane lesions formed by holins and cleave it, thus, inducing lysis of the bacterial cell and enabling progeny virions to be released. Endolysins are also capable of degrading peptidoglycan when applied externally (as purified recombinant proteins) to the bacterial cell wall, which also results in a… 

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