Bacteriological and Clinical Evaluation of Sisomicin, a New Aminoglycoside Antibiotic

@inproceedings{Abbate1976BacteriologicalAC,
  title={Bacteriological and Clinical Evaluation of Sisomicin, a New Aminoglycoside Antibiotic},
  author={Gabriella Abbate and I. Alagia and V. Leonessa and Paolo Altucci},
  year={1976}
}
Sisomicin exerts a high antibacterial (bactericidal) activity against Pseudomonas, most Coliform Bacilli and Staphylococcus aureus strains. 
Sisomicin: a review of eight years' experience.
TLDR
The pharmacokinetics and toxicity of sisomicin in humans appear to be similar to those of gentamicin, despite earlier reports of greater acute toxicity in animals, and has been shown to be effective for treatment of severe infections in humans, including some infections caused by gentamicIn-resistant bacteria.

References

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In Vitro Bactericidal Effectiveness of Four Aminoglycoside Antibiotics
TLDR
The antibacterial activity of four aminoglycoside antibiotics (gentamicin, Sch 13706, tobramycin, and sisomicin) was tested against eight gram-negative and three gram-positive species and Gentamicin was most effective against Serratia.
Gentamicin-Adenylyltransferase Activity as a Cause of Gentamicin Resistance in Clinical Isolates of Pseudomonas aeruginosa
TLDR
Gentamicin adenylyltransferase activity was found in extracts of clinical isolates of gentamicin-resistant Pseudomonas aeruginosa, and may be added to acetylation as an enzymatic mechanism responsible for Gentamicin resistance among strains of P. aerug inosa.