Bacteriologic response to oral cephalosporins: are established susceptibility breakpoints appropriate in the case of acute otitis media?

@article{Dagan1997BacteriologicRT,
  title={Bacteriologic response to oral cephalosporins: are established susceptibility breakpoints appropriate in the case of acute otitis media?},
  author={Ron Dagan and Oren N Abramson and Eugene Leibovitz and David Greenberg and Ruth Lang and Sivan Goshen and Pablo Yagupsky and Alberto Leiberman and Dan Marian Fliss},
  journal={The Journal of infectious diseases},
  year={1997},
  volume={176 5},
  pages={1253-9}
}
Bacteriologic response to cefuroxime axetil and cefaclor administered for 10 days was evaluated in acute otitis media (AOM) in patients aged 6-36 months. Middle ear fluid culture was obtained by tympanocentesis before treatment, on day 4 or 5 after initiation of treatment, and if clinical relapse occurred before day 17. Bacteriologic failure was observed in 32% of patients receiving cefaclor versus 15% of patients receiving cefuroxime axetil (P = .009). Failure rates increased with increasing… CONTINUE READING

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