Bacteriocin Production: a Probiotic Trait?

  title={Bacteriocin Production: a Probiotic Trait?},
  author={Alleson Dobson and Paul D. Cotter and Reynolds Paul Ross and Colin Hill},
  journal={Applied and Environmental Microbiology},
  pages={1 - 6}
ABSTRACT Bacteriocins are an abundant and diverse group of ribosomally synthesized antimicrobial peptides produced by bacteria and archaea. Traditionally, bacteriocin production has been considered an important trait in the selection of probiotic strains, but until recently, few studies have definitively demonstrated the impact of bacteriocin production on the ability of a strain to compete within complex microbial communities and/or positively influence the health of the host. Although… 
Lack of Heterogeneity in Bacteriocin Production Across a Selection of Commercial Probiotic Products
A culture-based assessment of the bacteriocinogenic ability of bacterial strains found in a variety of commercially available probiotic products suggests that bacteriOCin production is not being optimally harnessed as a probiotic trait.
Bacteriocins of Gram-positive bacteria: Features and biotherapeutic approach
Current information on the generalities, classification proposals, biosynthesis and transport systems involved in the bacteriocins secretion is review and the new approaches for its application in veterinary medicine and human health are focused on.
Gut microbiota as a source of novel antimicrobials
Some of the antimicrobial compounds that are produced by bacteria isolated from the gut environment, with a special focus on bacteriocins are summarized and the potential therapeutic application of these compounds to maintain homeostasis in the gut and the biocontrol of pathogenic bacteria is evaluated.
Bacteriocins: Properties and potential use as antimicrobials
The structure, classification, mode of operation, safety, and antibacterial properties of bacteriocins as well as their effect on foodborne pathogens and antibiotic‐resistant bacteria were extensively studied.
Pediocin-Like Antimicrobial Peptides of Bacteria
Pediocin-like bacteriocins (PLBs) possess high activity against pathogenic bacteria from Listeria and Enterococcus genera and could give a rise to a new group of antibiotics of narrow spectrum of activity.
Bacteriocin: the avenues of innovation towards applied microbiology
Bacteriocin is a type of peptide which works when bacteria become resistant to some antibiotic and has wide application in food industry to prevent the growth of pathogenic bacteria.
The Potential of Class II Bacteriocins to Modify Gut Microbiota to Improve Host Health
Several bacteriocin-producing strains of LAB and their isogenic non-producing mutants have potential probiotic properties at diverse levels as they promote favorable changes in the host without major disturbance in gut microbiota, which is important for normal gut functioning.
The Bacteriocinogenic Potential of Marine Microorganisms
The scientific substantiation of the relevance of the research on the biological properties of these peptides is associated with the prospect of industrial cultivation of their producers in maricultures, as well as with the use of bacteriocins for medical and veterinary purposes.
Bacteriocins of lactic acid bacteria: extending the family
This review focuses on the various types of bacteriocins that can be found in LAB and the organization and regulation of the gene clusters responsible for their production and biosynthesis, and considers the food applications of the prototype bacteriOCins from LAB.


The dual role of bacteriocins as anti- and probiotics
This review will report on recent efforts involving the use of bacteriocin-producing strains as probiotic and bioprotective agents, with a particular focus on emerging probiotic therapies for humans, livestock, and aquaculture.
Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118
It is demonstrated that Lactobacillus salivarius UCC118, a recently sequenced and genetically tractable probiotic strain of human origin, produces a bacteriocin in vivo that can significantly protect mice against infection with the invasive foodborne pathogen Listeria monocytogenes.
Recent advances in bacteriocin application as antimicrobials.
The ability to develop novel bacteriocin-based-drugs aimed at potential target cells, prokaryotic as well as eukaryotic, may open new possibilities for the design of improved antibiotics possessing refined characteristics.
Bacteriocins as oral and gastrointestinal antibiotics: theoretical considerations, applied research, and practical applications.
  • B. Kirkup
  • Biology
    Current medicinal chemistry
  • 2006
Experiments, based on an improved theoretical understanding of microbial ecology, demonstrate the in vivo activity of bacteriocins, the potential importance of bacter iocins as antibiotics, and the role that bacteriOCins play in antibiotic resistance.
Bacteriocins of lactic acid bacteria.
Understanding the mechanisms by which probiotics inhibit gastrointestinal pathogens.
Persistence of colicinogenic Escherichia coli in the mouse gastrointestinal tract
The data presented here support prior claims that bacteriocin production may play a significant role in the colonization of E. coli in the gastrointestinal tract and suggest that the ability to produce bacteriOCins may prove to be a critical factor in determining the success of establishing probiotic E. bacteria in humans and animals.
Production of plantaricin NC8 by Lactobacillus plantarum NC8 is induced in the presence of different types of gram-positive bacteria
The results suggest that the presence of specific gram-positive bacteria acts as an environmental stimulus activating both plantaricin NC8 production by L. plantarum NC8 and a PLNC8-autoinducing activity, which in turn triggers or maintains bacteriocin production in the absence of inducing cells.
Bacteriocins reduce Campylobacter jejuni colonization while bacteria producing bacteriocins are ineffective
Treatments with viable probiotic bacterial cultures were ineffective in reducing C. jejuni in chickens, while bacteriocin treatment from these corresponding bacteria substantially reduced C.Jejuni colonization in the live birds.
Fate and efficacy of lacticin 3147-producing Lactococcus lactis in the mammalian gastrointestinal tract.
Gastrointestinal survival of the bacteriocin-producing strain, Lactococcus lactis DPC6520, was evaluated systematically in vitro and in vivo to demonstrate that this strain is capable of surviving transit through the GIT, and yet lacks antimicrobial efficacy in the models of infection used.