Bactericidal monoclonal antibodies specific to the lipopolysaccharide O antigen from multidrug-resistant Escherichia coli clone ST131-O25b:H4 elicit protection in mice.

@article{Szijrt2015BactericidalMA,
  title={Bactericidal monoclonal antibodies specific to the lipopolysaccharide O antigen from multidrug-resistant Escherichia coli clone ST131-O25b:H4 elicit protection in mice.},
  author={Val{\'e}ria Szij{\'a}rt{\'o} and Luis M Guachalla and Zehra C. Visram and Katharina Hartl and Cec{\'i}lia Varga and Irina Mirkina and Jakub Zmajkovic and Adriana Badarau and Gerhild Zauner and Clara Pleban and Zolt{\'a}n Magyarics and Eszter Nagy and G{\'a}bor Nagy},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 6},
  pages={3109-16}
}
The Escherichia coli sequence type 131 (ST131)-O25b:H4 clone has spread worldwide and become responsible for a significant proportion of multidrug-resistant extraintestinal infections. We generated humanized monoclonal antibodies (MAbs) that target the lipopolysaccharide O25b antigen conserved within this lineage. These MAbs bound to the surface of live bacterial cells irrespective of the capsular type expressed. In a serum bactericidal assay in vitro, MAbs induced >95% bacterial killing in the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Similar Papers

Loading similar papers…