Bactericidal effects of polyhexamethylene biguanide against intracellular Staphylococcus aureus EMRSA-15 and USA 300.

@article{Kamaruzzaman2016BactericidalEO,
  title={Bactericidal effects of polyhexamethylene biguanide against intracellular Staphylococcus aureus EMRSA-15 and USA 300.},
  author={Nor Fadhilah Kamaruzzaman and Rebuma Firdessa and Liam Good},
  journal={The Journal of antimicrobial chemotherapy},
  year={2016},
  volume={71 5},
  pages={1252-9}
}
OBJECTIVES The treatment of skin infections caused by Staphylococcus aureus is limited by acquired antibiotic resistance and poor drug delivery into pathogen and host cells. Here, we investigated the antibacterial activities of six topically used antimicrobials and a cationic polymer, polyhexamethylene biguanide (PHMB), against intracellular MSSA strain RN4420 and MRSA strains EMRSA-15 and USA 300. METHODS The MICs of antimicrobials were determined for MSSA and MRSA strains, and the… CONTINUE READING
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